Pieter Dorrestein is the Director of the Therapeutic Discovery Mass Spectrometry Center and a Co-Director, Institute for Metabolomics Medicine in the Skaggs School of Pharmacy & Pharmaceutical Sciences, Departments of Pharmacology, Chemistry and Biochemistry. Dr. Dorrestein was trained by Tadgh Begley in the chemical biology of enzymes involved in vitamin biosynthesis and by Neil Kelleher and Christopher Walsh, whom were co-sponsors of his NRSA postdoctoral fellowship, in Top and Middle down mass spectrometry on proteins that made small molecules of therapeutic value. Since his arrival to UCSD in 2006, Dr. Dorrestein has been pioneering the development of mass spectrometry methods to study the chemical and ecological crosstalk between population of organisms for agricultural, diagnostic and therapeutic applications.
A "GoogleMAP"-type view of specialized molecules from microbes, their communities and hosts including people
(Marica Hall, Jun 26th, 13:40)
Chemical crosstalk between cell populations is a universal phenomena. The chemistry involved in this crosstalk is very diverse and therefore capturing this information represents an analytical challenge especially since there are no amplification methods such as PCR used in sequencing. In this talk we will highlight the mass spectrometry based workflows that the lab has developed to increase our ability to tease apart the molecular components of interacting microbes and microbial communities in 2D and 3D. In our lab we are referring to this as our “Google-Map streetview” for molecular space and are developing a crowd source approach to characterize the signals detected by mass spectrometry of biological samples. The examples highlighted in this talk will range from interacting microbes such as P. aeruginosa with C. albicans, microbial communities such as lichen and sputa obtained from cystic fibrosis patients as well as molecular maps of molecular-microbial communities of people.
Department of Pharmacology, Department of Chemistry and Biochemistry, University of California - San Diego, USA